May 22, 2026
Photozyme explains how to get rid of age spots with topical treatments, DNA repair technology, professional procedure...
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Dermatologist-Approved
80%
of visible skin aging is caused by UV-induced DNA damage
93%
reduction in CPD formation vs. sunscreen alone in clinical trials
3
Nobel Prize-winning DNA repair pathways at work
see the results for yourself
These before-and-after images document a 90-day trial using Photozyme daily. The user evaluated the serum over three months to see whether DNA repair skincare could visibly improve sun damage, skin tone, and signs of aging.
Most skincare works on the surface. Photozyme works deeper.
Sun exposure, environmental stress, and time don't just age the surface of your skin. They damage the DNA inside your skin cells — the biological blueprint that controls how your skin looks, functions, and repairs itself.
Left uncorrected, this damage accumulates, leading to dark spots, fine lines, loss of firmness, and increased skin cancer risk. Photozyme MD combines three clinically studied DNA repair enzymes that work with your skin's natural repair mechanisms to help address UV-induced DNA damage before it becomes more visible
What Even Is DNA Damage?
Think of your skin cells like tiny computers. Inside each one is a set of instructions — your DNA — that tells the cell how to grow, repair, and stay healthy. UV rays corrupt those instructions.
The UV Assault
When UV rays hit your skin, they physically fuse DNA building blocks together — like a virus corrupting a file. The cell tries to copy damaged code, producing mutations and early aging.
Oxidative Damage
UV exposure creates free radicals — unstable molecules that damage DNA like a pinball machine. They corrupt guanine, a critical DNA building block, causing mutations when copied into new cells.
Cyclobutane Pyrimidine Dimers
The most common UV-induced DNA lesion. UV rays smash DNA building blocks together into fused pairs called CPDs that scramble your DNA's instructions — and standard sunscreen cannot reverse them.
Your Skin Can't Keep Up
Your skin has a built-in repair system — but sun damage can happen faster than your skin can keep up. The sun is responsible for more than 80% of the visible damage we see on skin over time.
Meet the Three Enzymes
Each enzyme targets a different type of UV-induced DNA damage. Together, they create a comprehensive repair system that works the way your skin was always meant to.
01
Photolyase
Plankton Extract
The Problem It Fixes
UV rays fuse pairs of DNA building blocks together — creating CPDs that scramble your DNA's instructions. Like melting two puzzle pieces into one.
Derived from marine microorganisms that evolved over millions of years to survive intense UV exposure. Photolyase finds fused DNA pairs, locks onto them, and uses light energy to pull them apart — restoring the original structure.
Simply put Photolyase finds where the sun broke your DNA and puts it back together.
02
OGG1
Arabidopsis Thaliana Extract
The Problem It Fixes
Free radicals created by UV hit guanine — a DNA building block — turning it into corrupted 8-oxoguanine. If copied into new cells, it causes mutations.
Derived from Arabidopsis thaliana — a plant with no shade, no sunscreen, that spent millions of years in direct sunlight. OGG1 Glycosylase scans your DNA like a spell-checker: spots the corrupted guanine, removes it cleanly, and signals your cell to fill in the correct piece.
OGG1 is your DNA's spell-checker — it finds the bad letters and replaces them with the right ones.
03
Endonuclease
Micrococcus Lysate
The Problem It Fixes
Like Photolyase, T4 Endonuclease V also targets fused DNA pairs caused by UV — but with a completely different and complementary approach.
From Micrococcus luteus — a bacterium living in desert soils and high in the atmosphere, exposed to some of the most intense UV radiation on earth. Rather than reversing DNA fusion, Endonuclease cuts out the damaged section entirely and calls in your cell's own repair crew to rebuild it correctly.
A GPS-guided demolition tool — finds exactly where the sun broke your DNA, marks the spot, and signals your skin to tear it out and rebuild it good as new.
Why Three Enzymes?
Because sun damage isn't one thing. UV rays cause multiple types of DNA damage simultaneously — and each enzyme in The Photozyme Method is designed to address a different type. Together, they create a comprehensive repair system that works the way your skin was always meant to.
How the Enzymes Get Inside Your Skin
Enzymes are large molecules. Without a delivery system, they sit on the surface. Liposomes — microscopic bubbles made from the same material as your cell membranes — carry them in.
pack
Each DNA repair enzyme is loaded inside a liposome before it enters the formula.
Enter
The liposome blends with your skin's natural oils and moves through the outer barrier.
Merge
Once it reaches the living cell layers, the liposome merges with the cell membrane.
Release
The enzyme is released directly inside the cell — exactly where it needs to be.
Repair
The enzyme identifies damage, corrects it, and restores your DNA's original instructions.
Built on the Science
The Research Behind the Method
Photozyme's enzyme technology isn't new to science — it's new to skincare. The clinical foundation spans more than three decades of peer-reviewed research.
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Randomized controlled trials demonstrating measurable reductions in UV-induced DNA damage markers following topical enzyme application
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Skin biopsy studies confirming enzyme penetration and biological activity at the cellular level when delivered via liposomes
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Long-term studies showing reductions in actinic keratoses and precancerous lesions with consistent enzyme use
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Published research in leading dermatology journals including The Lancet and the Journal of Investigative Dermatology
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Pioneering work by Dr. Daniel Yarosh, whose decades of study on Endonuclease established the clinical framework for DNA repair in skincare
The Nobel Prize-Winning Science Behind DNA Repair.
In 2015, the Nobel Prize in Chemistry was awarded for one discovery — that cells have precise, elegant systems for repairing damaged DNA. Those same pathways are what The Photozyme Method is built on.
Trusted by 50,000+ Customers & Physicians
Every formula built on
this foundation.
We believe the best skincare doesn't just look good on your skin. It works inside it.
Free Shipping on US Orders $50+
60-Day Money-Back Guarantee
Dermatologist-Approved
Free Shipping on US Orders $50+
60-Day Money-Back Guarantee
Dermatologist-Approved
CLINICAL INSIGHTS ON SKIN HEALTH
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